Limonene is an aromatic monoterpene that is found naturally in the skins of citrus fruits (such as lemon, orange and grapefruit). It is one of the volatile compounds most abundant in these essential oils and contributes to its citrus aroma characteristic.
From a biomedical perspective, the properties of limonene have been investigated for their potential antioxidant, anti-inflammatory, neuroprotective, and metabolic-modulating effects.
Antioxidant and anti-Inflammatory Numerous studies indicate that the properties of limonene and essential oils rich in this compound to exert antioxidant activities and anti-inflammatory, reducing markers of oxidative stress and pro-inflammatory cytokines.
Anticancer Activity (Preclinical) Systematic reviews show that, thanks to the properties of limonene, this may have chemopreventive effects against various types of cancer, for example:
Inhibits the initiation and growth of the tumor.
Active routes of apoptosis in cancer cells.
Reduces angiogenesis and cell proliferation.
Gastrointestinal Health The properties of limonene have shown potential in experimental models to promote the dissolution of gallstones, to protect against gastrointestinal lesions and reduce inflammation of the intestinal tissue by increasing protective mucus.
Neuroprotection Against Neurological Diseases Scientific reviews suggest that the properties of limonene have high neuroprotective potential:
It may mitigate neuroinflammation and oxidative stress in diseases such as Alzheimer's and multiple sclerosis.
Beneficial effects against anxiety were observed in preclinical studies in preclinical studies.
Relationship to Neurotransmitter Transmission Research suggests that the properties of limonene modulate key neurotransmission systems, regulating levels of GABA and dopamine, which are essential in the regulation of mood.
Indirect effects Related to the Central Nervous System The studies suggest that the properties of limonene can exert anxiolytic effects and relaxing. The intake has been associated with changes in EEG activity that are correlated with states more relaxed. These results support the idea that the properties of limonene contribute indirectly to make it easier to sleep through the reduction of stress.
Anti-inflammatory and Antioxidant properties The properties of limonene act by reducing the production of reactive oxygen species and the activation of signaling pathways inflammatory.
Modulation of Neurotransmitters The anxiolytic-like activity of this compound, derived from the properties of limonene, can be mediated through receptors, such as A2A adenosine, involved in neuronal regulation.
Preclinical Evidence Predominant Although the properties of limonene are promising, the clinical evidence in humans remains the area of greatest growth to confirm all the proposed effects.
Safety and Tolerability Limonene is recognized as safe in normal quantities. The anxiolytic effect and relaxing associated to the properties of the limonene can indirectly facilitate falling asleep.
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